When initiating rosuvastatin therapy or switching from another statin, the appropriate initial dosage of rosuvastatin should be used; dosage may then be carefully adjusted according to individual requirements (i.e., percent reduction in low-density lipoprotein [LDL]-cholesterol concentration) and response Rosuvastatin CALCIUM. Rosuvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. Muscle problems, including muscle breakdown, can be serious in some people and rarely cause kidney damage that can lead to death Dosage adjustment for rosuvastatin with concomitant medications: Atazanavir/ritonavir, lopinavir/ritonavir, or simeprevir: Initiate rosuvastatin at 5 mg once daily (maximum: 10 mg/day). Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements). 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